Sure. It's easy enough to spray weeds with deadly chemicals like glyphosate. This kills them after being absorbed into the leaves and ending up in the roots. Every other plant exposed to overspray dies too - along with any insects and the micro herd that's in the way.
Here are a few earth friendly weed control methods that don't impact
innocent bystanders, or poison the soil and the critters that live in
Propane torch method. This one is from Amazon; One Shot BB-100 Propane Torch for Ice, Weeds and Asphalt
Solarization - this is a method of heating the soil
under plastic to kill pathogens, weeds and (if it's hot enough) weed
This is a great method to use when you're preparing a new planting bed and you want to get rid of everything and start with a clean slate.
Use black poly, in 4mil thickness or more, or a black rubber runner. Move it around occasionally.
with newspaper, cardboard or carpet, then covering that with organic
compost, wood chips, bark, straw or other organic material is a good
permanent solution in established beds, or on pathways.
Choose one or more of these Earth Friendly Weed Control methods to keep your garden relatively weed free - don't forget to leave some flowering weeds in a corner for the pollinators!